Drug-induced mitochondrial dysfunction

Sect. 1. Basic Concepts

1. Basic Mitochondrial Physiology in Cell Viability and Death / Lech Wojtczak and Krzysztof Zablocki

2. Basic Molecular Biology of Mitochondrial Replication / Immo E. Scheffler

3. Drug-Associated Mitochondrial Toxicity / Rhea Mehta, Katie Chan, Owen Lee, Shahrzad Tafazoli and Peter J. O'Brien

4. Pharmacogenomics of Mitochondrial Drug Toxicity / Neil Howell and Corinna Howell

Sect. 2. Organ Drug Toxicity - Mitochondrial Etiology

5. Features and Mechanisms of Drug-Induced Liver Injury / Dominique Pessayre, Alain Berson and Bernard Fromenty

6. Cardiovascular Toxicity of Mitochondrial Origin / Paulo J. Oliveira, Vilma A. Sardao and Kendall B. Wallace

7. Skeletal Muscle and Mitochondrial Toxicity / Timothy E. Johnson

8. Manifestations of Drug Toxicity on Mitochondria in the Nervous system / Ian J. Reynolds

9. Lipoatrophy and Other Manifestations of Antiretorviral Therapeutics / Ulrich A. Walker

10. Nephrotoxicity / Alberto Ortiz, Alberto Tejedor and Carlos Caramelo

11. Drug Effects in Patients with Mitochondrial Diseases / Eric A. Schon, Michio Hirano and Salvatore DiMauro

Sect. 3. Assessment of Mitochondrial Function in Vitro and in Vivo

12. Polarographic Oxygen Sensors, the Oxygraph, and High-Resolution Respirometry to Assess Mitochondrial Function / Erich Gnaiger

13. Use of Oxygen-Sensitive Fluorescent Probes for the Assessment of Mitochondrial Function / James Hynes, Tomas C. O'Riordan and Dmitri B. Papkovsky

14. Mitochondrial Dysfunction Assessed Quantitatively in Real Time by Measuring the Extracellular Flux of Oxygen and Protons / David Ferrick, Min Wu, Amy Swift and Andy Neilson

15. Assessment of Mitochondrial Respiratory Complex Function In Vitro and In Vivo / Mark A. Birch-Machin

16. OXPHOS Complex Activity Assays and Dipstick Immunoassays for Assessment of OXPHOS Protein Levels / Sashi Nadanaciva

17. Use of Fluorescent Reporters to Measure Mitochondrial Membrane Potential and the Mitochondrial Permeability Transition / Anna-Liisa Nieminen, Venkat K. Ramshesh and John J. Lemasters

18. Compartmentation of Redox Signaling and Control: Discrimination of Oxidative Stress in Mitochondria, Cytoplasm, Nuclei, and Endoplasmic Reticulum / Patrick J. Halvey, Jason M. Hansen, Lawrence H. Lash and Dean P. Jones

19. Assessing Mitochondrial Protein Synthesis in Drug Toxicity Screening / Edward E. McKee

20. Mitochondrial Toxicity of Antiviral Drugs: A Challenge to Accurate Diagnosis / Michel P. de Baar and Anthony de Ronde

21. Clinical Assessment of Mitochondrial Function via [[superscript 13]C]Methionine Exhalation / Laura Milazzo

22. Assessment of Mitochondrial Dysfunction by Microscopy / Ingrid Pruimboom-Brees, Germaine Boucher, Amy Jakowski and Jeanne Wolfgang

23. Development of Animal Models of Drug-Induced Mitochondrial Toxicity / Urs A. Boelsterli and Yie Hou Lee

24. Noninvasive Assessment of Mitochondrial Function Using Nuclear Magnetic Resonance Spectroscopy / Robert W. Wiseman and J. A. L. Jeneson

25. Targeting Antioxidants to Mitochondria by Conjugation to Lipophilic Cations / Michael P. Murphy.